Careers at Kapoose Creek Bio
Working at Kapoose Creek Bio
Kapoose Creek Bio is developing a new approach to drug discovery—one grounded in natural chemistry and accelerated by computation.
We explore the vast diversity of compounds produced by living systems and apply machine learning and advances in OMICs technologies to identify those with therapeutic potential. Our work brings together biology, chemistry, and data science to uncover signals that traditional approaches often miss.
We are a small, focused team working across disciplines, with a shared goal of translating natural insights into meaningful advances in human health.
Interdisciplinary by design
Our work sits at the intersection of computation and experimental science. We collaborate closely across domains.
Driven by evidence
We prioritize scientific rigor, clarity, and reproducibility in everything we do.
Focused and ambitious
We pursue difficult problems with a long-term perspective, aiming to uncover opportunities others overlook.
Open Positions
Vice President - Discovery Biology
VP level | Full-time
Location: McMaster Innovation Park, Hamilton, ON (On-site)
Build a Discovery Organization. Shape a Pipeline. Help Define a Company.
Kapoose Creek Bio is building a next-generation small-molecule discovery company.
Our platform combines natural product chemistry, AI-enabled phenotypic profiling, metabolomics, genomics, and translational biology to discover differentiated therapeutics from fungal biodiversity. We are advancing our lead neuroscience program toward in vivo validation while building a growing portfolio of novel opportunities in oncology and other therapeutic areas.
We are seeking an exceptional scientific leader to build and lead our Discovery Biology organization during the next phase of the company’s growth.
The Opportunity:
This is a rare opportunity to join the executive leadership team of an emerging biotechnology company and play a defining role in its scientific direction.
Working closely with the CEO/CSO, you will:
- Lead biology strategy across the company’s discovery portfolio.
- Build, mentor, and expand a high-performing biology team.
- Drive programs from early discovery through lead optimization and toward development candidates.
- Integrate biology with medicinal chemistry, computational discovery, pharmacology, biomarker development, and translational science.
- Establish external scientific collaborations and oversee CRO partnerships.
- Help prioritize a growing portfolio of therapeutic opportunities and contribute to corporate strategy.
- Represent the company with investors, partners, scientific advisors, and the Board.
The Ideal Candidate
We’re looking for an accomplished drug discovery leader who combines scientific excellence with outstanding leadership and sound strategic judgment.
You will have:
- A PhD, MD, or equivalent scientific training.
- Significant experience leading drug discovery programs within biotechnology or pharmaceutical R&D.
- A track record of advancing innovative therapeutics from discovery toward IND-enabling development.
- Experience building and leading multidisciplinary scientific teams.
- Strong expertise in translational biology and preclinical drug discovery.
- Experience managing external collaborations and CROs.
- Excellent communication skills and the ability to thrive in a fast-moving entrepreneurial environment.
Experience in neuroscience drug discovery is highly desirable, particularly experience developing novel CNS therapeutics. However, we welcome exceptional candidates whose leadership experience has been gained in other therapeutic areas and who are excited by the opportunity to help build a broad discovery platform.
Why Kapoose Creek Bio:
Our ambition extends well beyond a single therapeutic program. We are building a discovery engine capable of generating multiple first-in-class small-molecule therapeutics from one of the world’s most distinctive natural product collections.
This role offers the opportunity to shape scientific strategy, build an outstanding biology organization, and make a lasting impact on the future of the company.
Apply:
Send your CV and cover note to:
careers@kapoosecreekbio.com
While we thank all applicants, only those selected for an interview will be contacted. Confidential inquires and nominations are welcome
Associate Scientist (Fermentation & Natural Products)
Early-career | Full-time, laboratory-based
Location: McMaster Innovation Park, Hamilton, ON (On-site)
The Opportunity:
We are seeking a hands-on, highly motivated microbiologist to support our microbial fermentation and natural products workflows. This role is ideal for an early-career scientist who enjoys working at the bench and is excited to contribute in a fast-paced, collaborative biotech environment.
In this position, you will execute microbial fermentation experiments across a range of scales, working with both liquid and solid-state systems. You’ll prepare media and cultures, carry out routine microbiology assays, and generate high-quality experimental data to support ongoing discovery programs.
The role also offers exposure to adjacent chemistry workflows, including basic compound isolation and analytical support, providing a unique opportunity to work at the interface of biology and chemistry.
Qualifications & Requirements:
- Bachelor’s or Master’s degree in microbiology or a related field
- Hands-on microbiology laboratory experience through coursework, research, or industry
- Familiarity with microbial culturing, fermentation, and standard lab instrumentation
- Strong organizational skills and attention to detail
- Interest in learning new techniques and contributing across functions
Why Kapoose Creek Bio:
We are a dynamic, highly collaborative organization working at the interface of biology, chemistry, and AI, with a shared goal of unlocking new regions of natural chemical space for therapeutic discovery.
This is an opportunity to gain meaningful experience in drug discovery while contributing directly to active scientific programs. If you’re energized by that challenge, we’d love to hear from you.
The role is full-time and laboratory-based, reporting to the Director of Microbiology.
Apply:
Send your CV and cover note to:
careers@kapoosecreekbio.com
While we thank all applicants, only those selected for an interview will be contacted.
